Grape antidepressants suppress inflammation and help in setting up neuronal synapses.


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Researchers from the medical center of mount Sinai wrote in his article in Nature Communications that they were able to find in grapes two substances that suppress the depression: Dihydrocodeine acid and malvidin-3’-O-glucoside.

However, it is more accurate to say that they did not find them, and determined that the grapes have something that alleviates symptoms of depression, it was known rather for a long time. However, no one knew, nor what kind of material or how they act, only knew that grape energizers are polyphenols – a broad class of substances, known for its variety of effects, beneficial to health . (About the grape polyphenol resveratrol say that it helps the immune system to fight infections, about polyphenols from black tea – they help to work the intestinal microflora, but about polyphenols from strawberries – they all inhibit the growth of cancer cells.)

In the case of Dihydrocodeine acid and malvidin-3’-O-glucoside a particularly important mechanism of action. In connection with depression usually remember about neurotransmitters, about the serotonin with dopamine and certain other – it is believed that the disease is rooted in the fact that either too few, or they do not work as it should; and most of the antidepressants focus just on that to fix problems with the neurotransmitters. But really only it goes beyond this.

It is known that depression increases the inflammatory background, in other words, you have a problem with the immune system; in addition, changes in the structure of neuronal connections – synapses. That is, it’s not just that the synapses aren’t doing too well neuromediatory, but what do synapses are formed and break up not to the brain – as they say, impaired synaptic plasticity, whereby the brain adapts to different conditions and with which he can solve a variety of tasks.

Grape antidepressants are just on the immune system and on the dynamics of synapses, and do not act directly on these processes, but the relevant genes. Dihydrocodeine acid inhibits the activity of the gene encoding the interleukin 6 – an immune signaling protein that is synthesized by macrophages and T-lymphocytes and amplifying the immune inflammatory response. Malvidin-3’-O-glucoside, on the contrary, stimulates activity of genes that are required for reformatting synapses. In experiments with mice, both substances reduced the symptoms of depression caused by regular stress and easing depression has been shown to decrease inflammation and active synaptic reorganizations in the brain.

The authors believe that the grape antidepressants can help those who do not help ordinary means. As you know, antidepressants are not always and not everyone, and probably this is because they focus only on neurotransmitter problems, and the lack of inflammation and synaptic plasticity remain as it was. Substances from grapes, perhaps, hardly in a position to eliminate severe forms of depression, but in combination with other therapeutic agents, they can become sick for real salvation.